Scientific Name: Felis catus
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae
Summary: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0028 | 2021.04 | 10X Genomics | Esophagus | Normal | 1928 | Link |
| Vthunter_0029 | 2021.04 | 10X Genomics | Eyelid | Normal | 679 | Link |
| Vthunter_0030 | 2021.04 | 10X Genomics | Heart | Normal | 8209 | Link |
| Vthunter_0031 | 2021.04 | 10X Genomics | Kidney | Normal | 2831 | Link |
| Vthunter_0032 | 2021.04 | 10X Genomics | Liver | Normal | 7889 | Link |
| Vthunter_0033 | 2021.04 | 10X Genomics | Lung | Normal | 8591 | Link |
| Vthunter_0034 | 2021.04 | 10X Genomics | Rectum | Normal | 1503 | Link |
Featureplot of receptors
Expression: Biased expression in brain (RPKM 11.8) and gall bladder (RPKM 0.8)
